Why the study?
Does pregnancy or exogenous hormone treatment alter basal and stretch-induced atrial natriuretic factor (ANF) secretion in rats?
Population
Conscious virgin female rats, pregnant rats, postpartum rats, and ovariectomized rats.
Comparison
Pregnancy, postpartum state, atrial distension… vs Basal conditions and acyclic rats without…
Design
Preclinical
Follow-up
Up to 1 week postpartum
Authors
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Pregnancy-attenuated ANF secretion in rats should not change clinical volume management; leaves open hormonal modulation of ANF in human pregnancy.
Does pregnancy or exogenous hormone treatment alter basal and stretch-induced atrial natriuretic factor (ANF) secretion in rats?
Pregnancy and the postpartum state attenuate stretch-induced atrial natriuretic factor secretion in rats, while oestradiol appears to stimulate basal secretion.
Zhang et al. (1995) studied this question.
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