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May 1, 1994AJP Regulatory Integrative and Comparative Physiology

Influence of pregnancy on ANF release from isolated atria

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Population

Isolated perfused right atria from virgin cycling rats and from rats at 7, 14, and 21 days of pregnancy

Comparison

Intraluminal pressure raised from basal control… vs Basal control level / unmated virgin rats

Design

Preclinical

Authors

SKSusan KaufmanHeritage FoundationYDYiming DengCentral South UniversityWTWendy R. ThaiUniversity of Alberta

Discussion

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Implication

Altered atrial secretory function may blunt ANF release in late rat pregnancy; leaves open relevance to human gestational volume regulation.

Structured PICO

P
Population
Isolated perfused right atria from virgin cycling rats and from rats at 7, 14, and 21 days of pregnancy
I
Intervention
Intraluminal pressure raised from basal control level (atmospheric) to 4, 6, and 10 cmH2O
C
Comparator
Basal control level (atmospheric) / unmated virgin rats
O
Outcome
Basal and stretch-induced release of atrial natriuretic factor (ANF) into the perfusatesurrogate

Pregnancy-induced changes in atrial tissue secretory characteristics, rather than changes in atrial filling, appear to blunt stretch-induced ANF release in late pregnancy.

Cite This Study

Kaufman et al. (1994) studied this question.

synapsesocial.com/papers/6a82a1d2fdcaa17bff6d0550https://doi.org/10.1152/ajpregu.1994.266.5.r1605
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial natriuretic factor release during pregnancy in rats.1995 · 18 citations
  2. 2Effect of atrial natriuretic factor in rat pregnancy1986 · 26 citations
  3. 3Plasma levels of atrial natriuretic peptides during pregnancy and post partum in the rat1989 · 12 citations
  4. 4Atrial natriuretic factor in pregnancy and pregnancy-induced hypertension1991 · 16 citations
  5. 5Interrelationships among atrial peptides, renin, and blood volume in pregnant rats1988 · 30 citations