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April 1, 1986AJP Regulatory Integrative and Comparative Physiology

Effect of atrial natriuretic factor in rat pregnancy

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Why the study?

Does atrial natriuretic factor (ANF) infusion elicit similar renal and vascular responses in pregnant versus virgin rats?

Population

Pregnant (term gravid) and virgin Sprague-Dawley rats

Comparison

Atrial natriuretic factor / atriopeptin II… vs Virgin Sprague-Dawley rats (age-matched controls)

Design

Preclinical

Authors

CKC. G. KristensenYNYutaka NakagawaUniversity of ShizuokaFCF. L. CoeThe Christie NHS Foundation Trust

Discussion

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Implication

ANF responsiveness preserved when volume-adjusted in pregnant rats; leaves open whether ANF-volume resetting applies in human gestation.

Structured PICO

Does atrial natriuretic factor (ANF) infusion elicit similar renal and vascular responses in pregnant versus virgin rats?

P
Population
Pregnant (term gravid) and virgin Sprague-Dawley rats
I
Intervention
Atrial natriuretic factor (ANF) / atriopeptin II (AP II) infusion
C
Comparator
Virgin Sprague-Dawley rats (age-matched controls)
O
Outcome
Renal (natriuretic response, diuresis) and vascular (blood pressure decrements) responsiveness to ANFsurrogate

Despite a 70% increase in intravascular volume during gestation, cardiac ANF content and renal/vascular responsiveness to ANF remain similar to virgin rats when adjusted for extracellular volume, suggesting a resetting of ANF-volume relationships in pregnancy.

Cite This Study

Kristensen et al. (1986) studied this question.

synapsesocial.com/papers/6a8b0418210b9ed19c893fcchttps://doi.org/10.1152/ajpregu.1986.250.4.r589
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial natriuretic factor release during pregnancy in rats.1995 · 18 citations
  2. 2Influence of pregnancy on ANF release from isolated atria1994 · 6 citations
  3. 3Plasma Concentrations of Atrial Natriuretic Factor in Normal Pregnancy and Early Puerperium1989 · 10 citations
  4. 4Plasma levels of atrial natriuretic peptides during pregnancy and post partum in the rat1989 · 12 citations
  5. 5Effects of angiotensin II on plasma atrial natriuretic factor in nonpregnant and pregnant ewes1995 · 4 citations