Why the study?
Does fasudil reduce Angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice?
Population
6-month-old apolipoprotein E-deficient mice infused with Angiotensin II (1.44 mg x kg(-1) x d(-1)) for 1 month
Comparison
Fasudil (136 or 213 mg x kg x d in drinking water) vs Tap water
Design
Preclinical, randomly assigned
Follow-up
1 month
Authors
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Attenuates experimental AAA in mice; leaves open whether Rho-kinase inhibition merits human trials.
Does fasudil reduce Angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice?
Inhibition of Rho-kinase by fasudil attenuates Angiotensin II-induced abdominal aortic aneurysm formation in a mouse model by inhibiting apoptosis and proteolysis.
Wang et al. (2005) studied this question.
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