Why the study?
Do the SK channel enhancers DCEBIO and NS309 modulate the afterhyperpolarizing current and firing properties in CA1 hippocampal pyramidal neurons?
Population
Recombinant SK2 channels and CA1 hippocampal pyramidal neurons
Comparison
SK channel enhancers DCEBIO and NS309 vs 1-EBIO (prototype enhancer) and baseline
Design
Preclinical
Authors
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NS309 modulates CA1 excitability in slices; leaves open whether SK enhancers can treat hyperexcitability disorders.
Do the SK channel enhancers DCEBIO and NS309 modulate the afterhyperpolarizing current and firing properties in CA1 hippocampal pyramidal neurons?
NS309 is a potent and specific SK channel enhancer that modulates CA1 pyramidal neuron excitability, making it a potential tool for treating disorders linked to neuronal hyperexcitability.
Pedarzani et al. (2005) studied this question.
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