March 1, 2001Journal of Biological ChemistryOpen Access

Control of Electrical Activity in Central Neurons by Modulating the Gating of Small Conductance Ca2+-activated K+ Channels

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Structured PICO

Population

Cloned SK channels, hippocampal CA1 neurons, and cultured cortical neurons

Intervention

1-ethyl-2-benzimidazolinone (EBIO)

Outcome

SK channel gating (Ca2+ concentration-response relation, channel deactivation rate), afterhyperpolarization (AHP), and electrical excitabilitysurrogate

Modulating SK channel gating with EBIO effectively controls electrical excitability in central neurons.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports targeting SK channel gating to control central neuron excitability; leaves open clinical translation from this animal model.

Cite This Study

Pedarzani et al. (2001) studied this question.

synapsesocial.com/papers/6a9293960b68d46265a28eab https://doi.org/10.1074/jbc.m010001200

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Control of Electrical Activity in Central Neurons by Modulating the Gating of Small Conductance Ca2+-activated K+ Channels

Structured PICO

Discussion

Implication

Cite This Study

Control of Electrical Activity in Central Neurons by Modulating the Gating of Small Conductance Ca2+-activated K+ Channels

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider