Population
HeLa cells or derivatives of MCF-7 cells
Design
Preclinical
Authors
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Apoptosis suppression during productive infection may guide antiviral strategies; leaves open relevance to human poliovirus pathogenesis.
Poliovirus infection triggers apoptosis via cytochrome c efflux and caspase activation, but the virus suppresses this program during productive infection through aberrant procaspase-9 processing.
Belov et al. (2002) studied this question.
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