Population
A mammalian cell line generated to express the poliovirus 2A protease in an inducible manner utilizing the…
Comparison
Induction of poliovirus 2A protease expression vs Uninduced state
Design
Preclinical
Authors
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Hypothesis-generating for poliovirus cytopathogenesis; leaves open in vivo relevance and any translational potential.
Poliovirus 2A protease expression alone is sufficient to induce apoptosis in mammalian cells, likely through translation inhibition or cleavage of unidentified cellular targets.
Goldstaub et al. (2000) studied this question.
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