February 1, 1995Journal of VirologyOpen Access

Apoptosis-inducing and apoptosis-preventing functions of poliovirus

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Population

HeLa-S3 cells (subline)

Comparison

Poliovirus infection vs Uninfected cells, or cells treated with…

Design

Preclinical

Authors

ETElena A. TolskayaChumakov Institute of Poliomyelitis and Viral Encephalitides LRLyudmila I. RomanovaSiberian State Aerospace University MKMarina S. KolesnikovaRussian Academy of Sciences

Discussion

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Implication

Poliovirus apoptosis modulation needs human validation; leaves open its role in pathogenesis or antiviral strategies.

Structured PICO

Population

HeLa-S3 cells (subline)

Intervention

Poliovirus infection (permissive and nonpermissive, including guanidine-sensitive, guanidine-dependent, and temperature-sensitive mutants)

Comparator

Uninfected cells, or cells treated with actinomycin D or cycloheximide without poliovirus infection

Outcome

Apoptotic reaction (exit into cytoplasm, nucleolytic internucleosomal degradation of chromosomal DNA, compaction and fragmentation of chromatin, cellular shrinkage, and cytoplasmic blebbing)

Poliovirus exhibits both apoptosis-inducing and antiapoptotic functions, representing the first description of an antiapoptotic function for an RNA virus.

Cite This Study

Tolskaya et al. (1995) studied this question.

synapsesocial.com/papers/6a82a6ea72d82bb027239bc6 https://doi.org/10.1128/jvi.69.2.1181-1189.1995

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Apoptosis-inducing and apoptosis-preventing functions of poliovirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Apoptosis-inducing and apoptosis-preventing functions of poliovirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider