Population
Seven alleles of shaker-1 (sh1) mice
Design
Preclinical
Follow-up
life span
Authors
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Protein destabilization without mRNA change suggests post-transcriptional effects in myosin-VIIa mutants; leaves open relevance to human disease.
Mutations in myosin-VIIa in shaker-1 mice lead to motor dysfunction and protein destabilization without affecting mRNA expression.
Hasson et al. (1997) studied this question.
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