Key result
Cloning of human myosin-VIIa revealed two transcripts, with the longer encoding a myosin tail that includes a long repeat containing a novel MyTH4 domain and a talin-like domain.
Population
Human cDNA libraries (testis, lymphocytes) for cloning human myosin-VIIa
Design
Preclinical
Authors
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No immediate clinical impact on Usher syndrome; leaves open whether novel domains enable targeted therapies.
The cloning of human myosin-VIIa reveals novel domain structures, providing insight into the molecular basis of Usher syndrome 1B.
Chen et al. (1996) studied Usher syndrome 1B. Molecular cloning of human myosin-VIIa was evaluated on Cloning and characterization of human myosin-VIIa transcripts. Cloning of human myosin-VIIa revealed two transcripts, with the longer encoding a myosin tail that includes a long repeat containing a novel MyTH4 domain and a talin-like domain.
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