Why the study?
The molecular mechanisms governing the mechanochemistry of human myosin-7a remain poorly understood due to difficulties purifying stable, intact protein.
Design
In vitro biochemical, structural, and single-molecule motility study
Authors
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Recombinant human myosin-7a production enables direct mechanochemical studies; leaves open relevance to Usher syndrome mechanisms or therapies.
Key points are not available for this paper at this time.
Hollo et al. (2023) studied this question.
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