Key result
Native myosin VIIa is a calmodulin-binding protein and an actin-based motor, with Mg-ATPase activity stimulated by f-actin (Kcat 4.3 s-1) and moving actin filaments at 190 nm s-1.
Native myosin VIIa is a calmodulin-binding protein and a bona fide actin-based motor.
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May guide myosin VIIa studies in sensory cells; leaves open validation in mammalian disease models.
Udovichenko et al. (2002) studied this question. Native myosin VIIa was evaluated on Mechanoenzymatic properties (Mg-ATPase activity and sliding filament motility). Native myosin VIIa is a calmodulin-binding protein and an actin-based motor, with Mg-ATPase activity stimulated by f-actin (Kcat 4.3 s-1) and moving actin filaments at 190 nm s-1.
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