Key result
The human myosin-7a motor domain exhibits a rate-limiting, slow ADP release step resulting in a high duty ratio, and its kinetic and mechanical properties are sensitive to free Mg2+ ion concentrations.
Authors
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Does not inform clinical decisions; leaves open myosin-7a’s physiological role and therapeutic relevance.
Heissler et al. (2011) studied this question. Recombinant human myosin-7a motor domain was evaluated on Kinetic parameters (ATPase activity, ADP release). The human myosin-7a motor domain exhibits a rate-limiting, slow ADP release step resulting in a high duty ratio, and its kinetic and mechanical properties are sensitive to free Mg2+ ion concentrations.
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