Why the study?
Infants with congenital heart disease often have poor growth and altered body composition, motivating longitudinal description of their growth patterns.
Do infants with congenital heart disease have altered growth patterns and body composition compared to healthy infants?
Do infants with congenital heart disease have altered growth patterns and body composition compared to healthy infants?
Infants with congenital heart disease exhibit complex growth patterns characterized by early deficits in weight and length, but altered fat accretion by 9 months, particularly in those with single ventricle physiology.
Answers are grounded in this paper and cite their sources.
May inform serial growth monitoring in CHD infants; hypothesis-generating for adiposity differences by single-ventricle physiology.
Background: Infants with congenital heart disease (CHD) often have poor growth and altered body composition (fat and muscle accretion). Aim: Describe growth patterns in infants with CHD using interval weight, length, head circumference (HC), triceps (TSF), subscapular skinfolds (SSSF), and mid-upper arm circumference (MUAC) measurements. Subjects and Methods: A total of 120 infants enrolled: 48% healthy and 58% with CHD (45% single ventricle [SV]; 55% two ventricle [2V] physiology). Weight, length, HC, TSF, SSSF, and MUAC measured at 3-, 6-, 9-, and 12-months of age. Results: CHD infants had lower weight, length, and HC z-scores at 3-, 6-, and 9-months. At 9-months, infants with SV physiology had larger TSF and SSSF z-scores over 2V and healthy infants. Overall MUAC z-scores were smaller at 3- and 6-months in infants with CHD. Conclusison: Infants with CHD have a complex pattern of growth. Longitudinal growth and body composition measurements provide information to better understand this pattern.
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Irving et al. (2022) studied this question.
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