Why the study?
Does the Ang I vaccine PMD3117 achieve sustained antibody titres and block the renin system in patients with essential hypertension?
Population
27 patients with essential hypertension responsive to an ACEi or ARB
Comparison
Three or four injections of the Ang I vaccine… vs Aluminium hydroxide injections over a 6 week…
Design
RCT, randomly assigned, double-blind
Follow-up
Every 30 days until disappearance of antibody titre
Authors
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Reduces aldosterone excretion without lowering blood pressure; challenges clinical utility of Ang I vaccination for hypertension.
Does the Ang I vaccine PMD3117 achieve sustained antibody titres and block the renin system in patients with essential hypertension?
The PMD3117 vaccine generated a prolonged antibody response to Ang I and biochemical evidence of renin system blockade, but did not lower blood pressure in hypertensive patients.
Coltart et al. (2004) studied this question.
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