Population
AdipoR2-deficient mice
Design
Preclinical
Authors
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AdipoR2 modulation warrants caution due to beta-cell failure risk in mice; leaves open its net effect on human metabolic disease.
AdipoR2 deficiency in mice reduces initial diet-induced insulin resistance but ultimately promotes type 2 diabetes due to beta-cell failure.
Liu et al. (2006) studied this question.
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