Population
Chinese hamster ovary (CHO-K1) cells expressing Human ether-à-go-go-related gene (HERG) encoded K+ channels
Comparison
Elevation of external Ca2+ from 1.8 to 10 mM vs Baseline external Ca2+ concentration of 1.8 mM
Design
Preclinical
Authors
Loading...
Hypothesis-generating for Ca2+-HERG interactions; validation in native myocytes needed before clinical relevance.
Extracellular Ca2+ selectively alters the voltage-dependent activation, but not inactivation gating, of HERG K+ channels, indicating distinct voltage-sensing mechanisms for these processes.
Johnson et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: