Why the study?
Does azelnidipine reduce blood pressure during exercise without augmenting the sympathetic nervous system in patients with mild essential hypertension?
Population
10 patients (age, 36-69 years) with mild essential hypertension
Comparison
Azelnidipine 8.0 mg oral once daily for 4 weeks vs Placebo for 4 weeks (crossover design)
Design
RCT, Randomized crossover, Double-blind
Follow-up
4 weeks per treatment period
Authors
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Supports azelnidipine for exercise BP control in mild hypertension; extends RCT evidence for sympathetic-neutral dihydropyridine effects.
Does azelnidipine reduce blood pressure during exercise without augmenting the sympathetic nervous system in patients with mild essential hypertension?
Azelnidipine effectively lowers blood pressure at rest and during exercise without causing reflex sympathetic activation in patients with mild essential hypertension.
Arita et al. (1999) studied this question.