Why the study?
Is nondipper pulse rate associated with measures of cardiac overload (BNP and LVMI) in high-risk patients?
Is nondipper pulse rate associated with measures of cardiac overload (BNP and LVMI) in high-risk patients?
Nondipper pulse rate is associated with a higher prevalence of elevated BNP and increased LVMI in women, suggesting it may be a marker for cardiac overload in high-risk patients.
Answers are grounded in this paper and cite their sources.
May mark cardiac overload in high-risk patients; hypothesis-generating and should not yet change practice.
This study aimed to investigate the relationship between nondipper pulse rate ( PR ) and hypertensive target organ damage. Ambulatory blood pressure monitoring was conducted in 940 high‐risk Japanese patients enrolled in the Japan Morning Surge Home Blood Pressure Study. Nondipper PR was defined as (awake PR −sleep PR )/awake PR <0.1. The authors measured the patients' brain natriuretic peptide ( BNP ) and left ventricular mass index ( LVMI ). The nondipper PR group (n=213) had a significantly higher prevalence of high BNP (≥35 pg/ mL , 39.9% vs 26.1%; P <.001) than the dipper PR group (n=727). LVMI was significantly higher in the nondipper PR patients compared with the dipper PR patients among the women (mean LVMI : 111.3±32.4 vs 104.2±26.7 g/m 2 , P =.03) but not the men (mean LVMI : 117.6±32.0 vs 117.2±33.1 g/m 2 , P =.92). In conclusion, the nondipper PR was associated with cardiac overload.
No takes yet. Share an insight, caveat, or question.
Oba et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: