Debulking of Keloid Combined with Intralesional Injection of Methotrexate and Triamcinolone versus Intralesional Injection of Methotrexate and Triamcinolone

Background: Keloid is a major health problem all over the world, where its management is a complex problem.Objective: To find new mode of therapy for keloid by using intralesional injection of methotrexate and triamcinolon with or without debulking.Patient and Methods: This single blinded comparative therapeutic outpatient based study was done at the Department of Dermatology, Baghdad Teaching Hospital during the period from February 2011 to February 2013.A total of 27 patients with 61 lesions were enrolled in this work and consisted of 2groups; Group A (30 lesions): Treated by intralesional injection of combination of methotrexate and triamcinolone acetonide and repeated every month.Group B (31 lesions) Debulking was carried out first and then injection of combination of methotrexate and triamcinolone acetonide at time of operation similar to Group A.Evaluation was performed by scoring system with 5 criteria (redness, elevation, hardness, itching and tenderness).The response was graded as no response, minimal, moderate or complete response.