A highly efficient solvent‐free protocol for the Buchwald–Hartwig (hetero)arylation of anilines, diarylamines, and dialkylamines mediated by the expanded‐ring N‐heterocyclic carbene palladium complex (THP‐Dipp)Pd(cinn)Cl [THP‐Dipp = 1,3‐bis(2,6‐diisopropylphenyl)‐3,4,5,6‐tetrahydropyrimidin‐2‐ylidene; cinn = cinnamyl, 3‐phenylallyl] was developed. The catalytic protocol was efficient for the coupling of amines and (hetero)aryl chlorides and bromides bearing donor, acceptor, and bulky substituents.
No takes yet. Share an insight, caveat, or question.
Topchiy et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: