Why the study?
Does coronary artery bypass grafting alter platelet cyclooxygenase-2 expression?
Does coronary artery bypass grafting alter platelet cyclooxygenase-2 expression?
Coronary artery bypass grafting induces platelet COX-2 expression at day 5 post-surgery, which may have implications for post-operative platelet function.
May alter post-CABG aspirin responsiveness; hypothesis-generating for tailored antiplatelet strategies in prospective trials.
There are conflicting reports about the expression of cyclooxygenase (COX)-2 in human platelets. The present study describes a flow cytometric method for the measurement of platelet COX. Both COX-1 and COX-2 were shown to be expressed in platelets from patients undergoing a coronary artery bypass graft. There was a significant increase in COX-2 expression at day 5 as compared with pre-surgery values (mean fluorescence 12.31 +/- 0.88 versus 9.15 +/- 0.88; means +/- SEM, n = 7, P < 0.05), whereas COX-1 levels did not change (13.45 +/- 1.11 versus 12.38 +/- 1.41; n = 7, P > 0.05).
No takes yet. Share an insight, caveat, or question.
Weber et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: