Direction of Polymerization by the Avian Myeloblastosis Virus Deoxyribonucleic Acid Polymerase
Population
Avian myeloblastosis virus DNA polymerase (in vitro model)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
No immediate clinical implications for cardiovascular care; leaves open extension to human retroviral or cardiac models.
Structured PICO
P
Population
Avian myeloblastosis virus DNA polymerase (in vitro model)
I
Intervention
Oligonucleotide primer [5'-^(32)P](dT)_(10) and dideoxythymidine triphosphate
O
Outcome
Direction of polymerization (addition of mononucleotides at the 3'-OH of the primer)surrogate
The study demonstrates that avian myeloblastosis virus DNA polymerase synthesizes DNA by adding nucleotides to the 3'-OH end of a primer.
Cite This Study
Smoler et al. (1971) studied this question.