Why the study?
Does sevoflurane compared to desflurane increase biochemical markers of renal injury in fasting volunteers?
Population
16 fasting volunteers (n=9 for 4 hours, n=7 for 2 hours)
Comparison
Sevoflurane at 1.25 minimum alveolar anesthetic… vs Desflurane at 1.25 MAC at 2 L/min fresh gas flow…
Design
Other
Authors
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May warrant preferring desflurane or limiting sevoflurane duration; leaves open Compound A thresholds in surgical patients.
Does sevoflurane compared to desflurane increase biochemical markers of renal injury in fasting volunteers?
Sevoflurane anesthesia produces dose-related glomerular and tubular injury in humans, with a threshold between 80 and 168 ppm/h of exposure to Compound A.
Eger et al. (1997) studied this question.
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