Population
84 full-length cDNA clones representing individual genomes from a moderately virulent isolate of classical…
Design
Preclinical
Authors
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Ancestral reconstruction yields functional viruses from non-viable sequences; extends viral evolution tools but leaves open clinical translation.
Reconstruction of ancestral viruses is a useful tool for experimental and computational investigations of virulence and viral evolution, even from non-functional variants.
Fahnøe et al. (2015) studied this question.
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