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May 1, 1989AnesthesiologyOpen Access

Cardiovascular Safety and Actions of High Concentrations of I-653 and Isoflurane in Swine

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Why the study?

Does I-653 have a different margin of safety and cardiovascular profile compared to isoflurane in mechanically ventilated swine?

Population

Mechanically ventilated swine

Comparison

I-653 (new inhaled anesthetic) vs Isoflurane

Design

Preclinical

Authors

RWRichard B. WeiskopfCross-Cutting CardiologyMHMargot A. HolmesStanford UniversityIRIra J. RampilCitrix (Switzerland)

Discussion

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Implication

Suggests narrower safety margin for I-653 than isoflurane in swine; leaves open translation to human anesthesia.

Structured PICO

Does I-653 have a different margin of safety and cardiovascular profile compared to isoflurane in mechanically ventilated swine?

P
Population
Mechanically ventilated swine
I
Intervention
I-653 (new inhaled anesthetic)
C
Comparator
Isoflurane
O
Outcome
Ratio of fatal anesthetic concentration-to-MAC (margin of safety)safety

I-653 has a narrower margin of safety compared to isoflurane in swine, though cardiovascular collapse is unlikely during spontaneous ventilation as it exceeds the concentration producing apnea.

Cite This Study

Weiskopf et al. (1989) studied this question.

synapsesocial.com/papers/6a82bb6ffb68d755121c23d4https://doi.org/10.1097/00000542-198905000-00015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular Effects of 1653 in Swine1988 · 44 citations
  2. 2Epinephrine-induced Premature Ventricular Contractions and Changes in Arterial Blood Pressure and Heart Rate during I-653, Isoflurane, and Halothane Anesthesia in Swine1989 · 50 citations
  3. 3Potency (Minimum Alveolar Anesthetic Concentration) of Isoflurane Is Independent of Peripheral Anesthetic Effects1995 · 4 citations
  4. 4Disparity of Isoflurane Effects on Left and Right Ventricular Afterload and Hydraulic Power Generation in Swine1998 · 23 citations
  5. 5Pulsed Doppler and Two-dimensional Echocardiography1987 · 59 citations