What is the clinical evidence from this study?

Study design: Other. Population: Epinephrine-induced arrhythmias (n=8). Intervention: I653 vs. Isoflurane and halothane. Primary outcome: Rate of infusion of epinephrine needed to produce premature ventricular contractions.

What does this research mean for the field?

The arrhythmogenic threshold for epinephrine-induced premature ventricular contractions under I-653 (desflurane) anesthesia is similar to that of isoflurane and significantly higher than that of halothane. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1989Anesthesiology

Epinephrine-induced Premature Ventricular Contractions and Changes in Arterial Blood Pressure and Heart Rate during I-653, Isoflurane, and Halothane Anesthesia in Swine

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Key result

I653 and isoflurane require similar epinephrine doses to trigger PVCs, far exceeding halothane.

Why the study?

Does I653 anesthesia alter the threshold for epinephrine-induced premature ventricular contractions compared to isoflurane and halothane in swine?

Population

8 domestic swine

Comparison

I653 anesthesia at 0.7-0.8 and 1.1-1.2 MAC with… vs Isoflurane and halothane anesthesia at similar…

Design

Preclinical

Authors

RWRichard B. WelskopfGaertner (United States)EEEdmond I. EgerUniversity of Central Florida MHMargot A. HolmesStanford University

Discussion

Member takes

Implication

I653 and isoflurane may share similar epinephrine PVC thresholds unlike halothane in swine; leaves open human translation.

Structured PICO

Does I653 anesthesia alter the threshold for epinephrine-induced premature ventricular contractions compared to isoflurane and halothane in swine?

Population

8 domestic swine evaluated to compare the arrhythmogenic effects of I653, isoflurane, and halothane during epinephrine infusion.

Intervention

I653 anesthesia at 0.7-0.8 and 1.1-1.2 MAC with intravenously infused epinephrine

Comparator

Isoflurane and halothane anesthesia at similar MAC levels with intravenously infused epinephrine

Outcome

Rate of infusion of epinephrine needed to produce premature ventricular contractions (PVCs)surrogate

Main Result

Absolute Event Rate: 6.9% vs 5.7%

I653 and isoflurane have similar properties regarding epinephrine-induced arrhythmias, requiring higher epinephrine infusion rates to produce PVCs compared to halothane in a swine model.

Cite This Study

Welskopf et al. (1989) studied Epinephrine-induced arrhythmias (n=8). I653 vs. Isoflurane and halothane was evaluated on Rate of infusion of epinephrine needed to produce premature ventricular contractions. I653 and isoflurane required similar epinephrine infusion rates to produce PVCs (6.9 vs 5.7 mcg/kg/min), which were greater than that required during halothane anesthesia (1.3 mcg/kg/min).

synapsesocial.com/papers/6aa5baa77b142bbe3664bfb6 https://doi.org/10.1097/00000542-198902000-00019

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February 1, 1989Anesthesiology

Epinephrine-induced Premature Ventricular Contractions and Changes in Arterial Blood Pressure and Heart Rate during I-653, Isoflurane, and Halothane Anesthesia in Swine

View Full Paper

Ask AI

Bookmark

Key result

I653 and isoflurane require similar epinephrine doses to trigger PVCs, far exceeding halothane.

Why the study?

Does I653 anesthesia alter the threshold for epinephrine-induced premature ventricular contractions compared to isoflurane and halothane in swine?

Population

8 domestic swine

Comparison

I653 anesthesia at 0.7-0.8 and 1.1-1.2 MAC with… vs Isoflurane and halothane anesthesia at similar…

Design

Preclinical

Authors

RWRichard B. WelskopfGaertner (United States)EEEdmond I. EgerUniversity of Central Florida MHMargot A. HolmesStanford University

Discussion

Member takes

Implication

I653 and isoflurane may share similar epinephrine PVC thresholds unlike halothane in swine; leaves open human translation.

Structured PICO

Does I653 anesthesia alter the threshold for epinephrine-induced premature ventricular contractions compared to isoflurane and halothane in swine?

Population

8 domestic swine evaluated to compare the arrhythmogenic effects of I653, isoflurane, and halothane during epinephrine infusion.

Intervention

I653 anesthesia at 0.7-0.8 and 1.1-1.2 MAC with intravenously infused epinephrine

Comparator

Isoflurane and halothane anesthesia at similar MAC levels with intravenously infused epinephrine

Outcome

Rate of infusion of epinephrine needed to produce premature ventricular contractions (PVCs)surrogate

Main Result

Absolute Event Rate: 6.9% vs 5.7%

I653 and isoflurane have similar properties regarding epinephrine-induced arrhythmias, requiring higher epinephrine infusion rates to produce PVCs compared to halothane in a swine model.

Cite This Study

synapsesocial.com/papers/6aa5baa77b142bbe3664bfb6 https://doi.org/10.1097/00000542-198902000-00019

Also Consider

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