What question did this study set out to answer?

To evaluate whether integrating the anatomical SYNTAX Score with a modified ACEF clinical risk score improves the prediction of long-term mortality and major adverse cardiovascular and cerebrovascular events (MACCE) following percutaneous coronary intervention.

July 21, 2010Circulation Cardiovascular InterventionsOpen Access

A New Tool for the Risk Stratification of Patients With Complex Coronary Artery Disease

View Full Paper

Ask AI

Bookmark

Why the study?

Does the Clinical SYNTAX Score improve the prediction of mortality and MACCE in patients with complex coronary artery disease undergoing PCI compared to the SYNTAX Score alone?

Population

512 patients with complex coronary artery disease undergoing percutaneous coronary intervention enrolled in…

Comparison

Risk stratification using the Clinical SYNTAX… vs SYNTAX Score alone and ACEF score alone

Design

Cohort

Follow-up

1 and 5 years

Authors

SGScot GargInterventional / Structural Cardiology GSGiovanna SarnoInterventional Cardiology HGHéctor M. García‐GarcíaInterventional Cardiology

Discussion

Member takes

Implication

Combining the SYNTAX Score with clinical variables (age, ejection fraction, creatinine clearance) into the Clinical SYNTAX Score improves the prediction of 5-year mortality and MACCE in patients undergoing PCI for complex CAD.

Key Points

To evaluate whether integrating the anatomical SYNTAX Score with a modified ACEF clinical risk score improves the prediction of long-term mortality and major adverse cardiovascular and cerebrovascular events (MACCE) following percutaneous coronary intervention.
Calculated the Clinical SYNTAX Score (CSS) in 512 patients from the ARTS-II study (NCT00235170) who had baseline serum creatinine, ejection fraction, and body weight recorded.
Stratified patients into CSS tertiles—CSS-low (≤15.6, n=170), CSS-mid (15.6–27.5, n=171), and CSS-high (>27.5, n=171)—to evaluate clinical outcomes at 1- and 5-year follow-up.
Patients in the highest CSS tertile had significantly higher rates of repeat revascularization and MACCE at 1 year, and higher rates of repeat revascularization, overall MACCE, and a trend toward higher mortality at 5-year follow-up compared with lower tertiles.
The C-statistic for predicting 5-year mortality was 0.69 for CSS versus 0.62 for the SYNTAX Score and 0.65 for the ACEF score.
The C-statistic for predicting 5-year MACCE was 0.62 for CSS versus 0.59 for the SYNTAX Score and 0.57 for the ACEF score.

Structured PICO

Does the Clinical SYNTAX Score improve the prediction of mortality and MACCE in patients with complex coronary artery disease undergoing PCI compared to the SYNTAX Score alone?

Population

512 patients with complex coronary artery disease undergoing percutaneous coronary intervention (PCI) enrolled in the ARTS-II study, who had serum creatinine levels, ejection fraction, and body weight recorded at baseline

Intervention

Risk stratification using the Clinical SYNTAX Score (CSS), calculated by multiplying the SYNTAX Score by a modified ACEF score

Comparator

SYNTAX Score alone and ACEF score alone

Outcome

Mortality and major adverse cardiovascular and cerebrovascular events (MACCE) at 1- and 5-year follow-upcomposite

Cite This Study

Garg et al. (2010) studied this question.

synapsesocial.com/papers/6a82bce6c40fc255ce133faf https://doi.org/10.1161/circinterventions.109.914051

Topics

Coronary artery disease

View Full Paper

Ask AI

Bookmark

A New Tool for the Risk Stratification of Patients With Complex Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A New Tool for the Risk Stratification of Patients With Complex Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider