This case report highlights a clinically significant drug-drug interaction between quinidine and warfarin that may lead to prolonged prothrombin time and hemorrhage.
May warrant prothrombin time monitoring with quinidine and warfarin; single case leaves interaction unconfirmed.
AN increasing number of drugs interact with warfarin sodium to alter the plasma prothrombin-complex content.1 2 3 4 Recently, Koch-Weser5 suggested that in some patients quinidine sulfate acts synergistically with warfarin to prolong the plasma prothrombin time.Case ReportA 48-year-old man was admitted to the Peter Bent Brigham Hospital in November, 1967, for aortic-valve replacement. In the previous August a diagnosis of aortic stenosis and coronary-artery disease was made, and quinidine, 200 mg by mouth 3 times daily, was given for premature atrial contractions. There was no history of liver disorder. Physical examination showed a murmur consistent with aortic stenosis.Urinalysis, complete . . .
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Gazzaniga et al. (1969) studied this question.
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