Population
Human mesangial cells and HEK 293 cells expressing human Sloalpha (hSloalpha) with hbeta1, hbeta2, or hbeta4
Comparison
db-cGMP and hbeta1 antisense oligonucleotides vs hSloalpha expressed alone or with hbeta4…
Design
Preclinical
Authors
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Hypothesis-generating for beta1 in mesangial BK regulation; leaves open translation to renal physiology or disease.
The hbeta1 accessory protein is essential for the activation of human mesangial BK channels by the cGMP kinase pathway.
Kudlacek et al. (2003) studied this question.
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