This preclinical study demonstrates that somatic afferent inputs influence the sympathetic nervous system through both localized spinal and generalized supraspinal reflex pathways.
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Does not inform clinical practice; leaves open translation of dual sympathetic reflex pathways to human cardiovascular research.
In chloralose anaesthetized cats reflex discharges in thoracic and lumbar white rami were elicited by single shock stimulation of intercostal, spinal and hind limb nerves.2. In animals with an intact neuraxis single stimuli of sufficient strength usually elicited a white rami mass discharge having two distinct components. Following spinal transection only the late reflex component disappeared.3. The early (spinal) reflex component had its largest amplitude if the afferent volley entered the spinal cord at the same or an adjacent segment of the white ramus under observation, whereas the size of the late (supraspinal) component was rather independent of the segmental level of the afferent input.4. It was concluded that somatic afferent volleys have a twofold action on the sympathetic nervous system: a more generalized action via the supraspinal sympathetic reflex centres and a more circumscribed action on the preganglionic neurones at the segmental level.
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Sato et al. (1971) studied this question.
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