Population
Human phospholamban (PLN) pentamer
Comparison
Phosphorylation-mimicking mutation S16E vs Unphosphorylated state
Design
Preclinical
Authors
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Subtle dynamic changes from S16E may modulate phospholamban function; leaves open effects on cardiac calcium handling in vivo.
A phosphorylation-mimicking mutation in phospholamban alters the dynamics of its extramembrane portion without perturbing its overall pentameric structure.
Oxenoid et al. (2007) studied this question.
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