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July 25, 2005Proceedings of the National Academy of SciencesOpen Access

The structure of phospholamban pentamer reveals a channel-like architecture in membranes

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Population

Unphosphorylated human phospholamban (PLN) pentamer in dodecylphosphocholine micelles

Design

Preclinical

Authors

KOKirill OxenoidAmgen (Canada)JCJames J. ChouChinese Academy of Sciences

Discussion

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Overview

Atomic PLN pentamer structure suggests possible channel function in Ca²⁺ handling; hypothesis-generating for SERCA regulation, needs human validation.

Structured PICO

P
Population
Unphosphorylated human phospholamban (PLN) pentamer in dodecylphosphocholine micelles
I
Intervention
Solution NMR methods for atomic resolution structure determination
O
Outcome
Atomic resolution structure of the PLN pentamer

The atomic structure of the phospholamban pentamer reveals a channel-like architecture that may explain its role in regulating calcium pumps in heart muscle cells.

Cite This Study

Oxenoid et al. (2005) studied this question.

synapsesocial.com/papers/6a82c32ac40fc255ce134142https://doi.org/10.1073/pnas.0504920102
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Transmembrane Helix Dimer: Structure and Implications1997 · 975 citations
  2. 2A Leucine Zipper Stabilizes the Pentameric Membrane Domain of Phospholamban and Forms a Coiled-coil Pore Structure1996 · 258 citations
  3. 3Phospholamban Inhibitory Function Is Activated by Depolymerization1997 · 286 citations
  4. 4Determination of three‐dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms Circumventing problems associated with folding1988 · 542 citations
  5. 5A novel approach for sequential assignment of proton, carbon-13, and nitrogen-15 spectra of larger proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin1990 · 925 citations