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November 1, 1997Hypertension

Endothelin-1 as an Autocrine/Paracrine Apoptosis Survival Factor for Endothelial Cells

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Population

Cultured endothelial cells obtained from rat aorta

Comparison

Endothelin-1 and ET receptor antagonists vs Serum starvation without ET-1 or with nonimmune…

Design

Preclinical

Authors

MSMasayoshi ShichiriKure Kyosai HospitalHKHiroki KatoKyushu UniversityFMFumiaki MarumoTokyo Institute of Technology

Discussion

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Implication

Hypothesis-generating for ETB-mediated endothelial survival in animals; leaves open any role in human vascular disease.

Structured PICO

P
Population
Cultured endothelial cells obtained from rat aorta
I
Intervention
Endothelin-1 (ET-1) (10[-12] to 10[-6] mol/L) and ET receptor antagonists (BQ788, PD142893, PD145065, BQ123)
C
Comparator
Serum starvation without ET-1 or with nonimmune rabbit serum
O
Outcome
Apoptotic death induced by serum starvationsurrogate

Endothelin-1 acts as an apoptosis survival factor for endothelial cells via the ET(B) receptor in an autocrine/paracrine manner.

Cite This Study

Shichiri et al. (1997) studied this question.

synapsesocial.com/papers/6a82c5efd88fdfcf4fa0cbb8https://doi.org/10.1161/01.hyp.30.5.1198
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Also Consider

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