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February 1, 1993Circulation Research

Age-related changes in sarcoplasmic reticulum Ca(2+)-ATPase and alpha-smooth muscle actin gene expression in aortas of normotensive and spontaneously hypertensive rats.

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Authors

TJThierry H. Le JemtelTulane University FLF. LambertUniversité Paris-Sud DLDmitri O. LevitskyCentre National de la Recherche Scientifique

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Implication

Reduced SERCA mRNA (actin-normalized) in adult SHR aortas; leaves open role in hypertensive vascular Ca2+ handling.

Key Points

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Cite This Study

Jemtel et al. (1993) studied this question.

synapsesocial.com/papers/6a82c6d91a90e54f711c2dce https://doi.org/10.1161/01.res.72.2.341

Topics

Hypertension management

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Molecular cloning and characterization of a Ca2+ + Mg2+-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum. Regulation of its expression by pressure overload and developmental stage.1989 · 156 citations
2Expression of endoplasmic-reticulum Ca2+-pump isoforms and of phospholamban in pig smooth-muscle tissues1990 · 136 citations
3(Ca2+ + Mg2+)‐dependent ATPase mRNA from smooth muscle sarcoplasmic reticulum differs from that in cardiac and fast skeletal muscles1988 · 61 citations
4Calcium release by noradrenaline from central sarcoplasmic reticulum in rabbit main pulmonary artery smooth muscle.1985 · 112 citations
5Molecular Cloning of the Mammalian Smooth Muscle Sarco(endo)plasmic Reticulum Ca2+-ATPase1989 · 207 citations