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October 1, 1994Circulation ResearchOpen Access

Calcium-activated chloride current in rabbit coronary artery myocytes.

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Population

Enzymatically dispersed epicardial coronary artery smooth muscle cells from rabbits

Design

Preclinical

Authors

FLFred S. LambVanderbilt University Medical CenterKVKenneth A. VolkUniversity of IowaESE F ShibataUniversity of Iowa

Discussion

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Implication

Characterizes Ca-activated Cl current in rabbit coronary myocytes; leaves open its role in human vasoregulation or as therapeutic target.

Structured PICO

P
Population
Enzymatically dispersed epicardial coronary artery smooth muscle cells from rabbits
I
Intervention
Whole-cell patch-clamp techniques with depolarizing voltage pulses and pharmacological modulators (nifedipine, barium, Bay K 8644, DIDS, niflumic acid, caffeine)
O
Outcome
Electrophysiological properties of inward L-type calcium currents and calcium-activated chloride currents (amplitude, time course, reversal potential)surrogate

This preclinical study characterizes a calcium-activated chloride current in rabbit coronary artery smooth muscle cells that is voltage-dependent and sensitive to specific channel blockers.

Cite This Study

Lamb et al. (1994) studied this question.

synapsesocial.com/papers/6a82c6dfd88fdfcf4fa0cc1chttps://doi.org/10.1161/01.res.75.4.742
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium currents in isolated rabbit coronary arterial smooth muscle myocytes.1990 · 83 citations
  2. 2Large conductance calcium‐activated non‐selective cation channel in smooth muscle cells isolated from rat portal vein.1991 · 98 citations
  3. 3Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit.1986 · 460 citations
  4. 4Ca2+ channel activation and membrane depolarization mediated by Cl− channels in response to noradrenaline in vascular myocytes1991 · 89 citations
  5. 5A transient calcium‐dependent chloride current in the immature Xenopus oocyte.1983 · 630 citations