Key result
Left atrial surgical ablation significantly increased the presence of sinus rhythm at 1 year compared to no ablation (60.2% vs. 35.5%, P=0.002) but did not improve clinical outcomes.
Why the study?
Does left atrial surgical ablation improve sinus rhythm restoration in patients with atrial fibrillation undergoing valve and/or coronary surgery?
Population
224 patients with atrial fibrillation (AF) scheduled for valve and/or coronary surgery
Comparison
Left atrial surgical ablation during cardiac… vs Cardiac surgery without atrial ablation
Design
RCT, randomized
Follow-up
1 year
Authors
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Rhythm benefit without clinical gains at 1 year; confirms ablation efficacy for sinus rhythm but challenges outcome expectations in surgical AF.
RCT (n=224)
randomized
Yes
Does left atrial surgical ablation improve sinus rhythm restoration in patients with atrial fibrillation undergoing valve and/or coronary surgery?
Absolute Event Rate: 60.2% vs 35.5%
p-value: p=0.002
Left atrial surgical ablation during cardiac surgery significantly increases the likelihood of sinus rhythm at 1 year, particularly in longstanding persistent AF, but does not improve 1-year clinical outcomes.
Budera et al. (2012) conducted an RCT in Atrial fibrillation with coronary and/or valvular heart disease (n=224). Left atrial surgical ablation vs. No ablation was evaluated on Sinus rhythm presence (without any AF episode) during a 24 h electrocardiogram after 1 year (p=0.002). Left atrial surgical ablation significantly increased the presence of sinus rhythm at 1 year compared to no ablation (60.2% vs. 35.5%, P=0.002) but did not improve clinical outcomes.
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