Key result
A computational model revealed that long-term control of arterial blood pressure is primarily mediated by the baroreflex arc and renin-angiotensin system, and arterial stiffening sufficiently explains aging-associated primary hypertension.
Population
Computational model of the cardiovascular system
Design
Other
Authors
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Questions kidney primacy in long-term BP control; leaves open arterial stiffening as driver of age-related hypertension pending validation.
A novel computational model suggests that long-term blood pressure control is driven by the baroreflex and renin-angiotensin system, challenging the dominant role of the kidneys, and attributes age-related primary hypertension to arterial stiffening.
Beard et al. (2013) studied Primary hypertension. Arterial stiffening (computational simulation) vs. Normal arterial compliance was evaluated on Long-term control of arterial blood pressure. A computational model revealed that long-term control of arterial blood pressure is primarily mediated by the baroreflex arc and renin-angiotensin system, and arterial stiffening sufficiently explains aging-associated primary hypertension.
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