Key result
A modified hydraulic model of the circulation demonstrates that long-term arterial pressure is a sole function of renal behavior and daily sodium intake, independent of other cardiovascular variables.
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Renal sodium handling dictates long-term BP in models; extends Guyton theory but leaves open clinical validation.
This theoretical model extends Guyton's classic diagram to illustrate the obligatory role of the kidney in long-term arterial blood pressure control.
Dorrington et al. (2009) studied Blood pressure regulation. Hydraulic model of circulation was evaluated. A modified hydraulic model of the circulation demonstrates that long-term arterial pressure is a sole function of renal behavior and daily sodium intake, independent of other cardiovascular variables.
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