Key result
High ANGPTL1 expression inversely correlates with invasion, lymph node metastasis, and poor clinical outcomes in patients with lung cancer.
Why the study?
Does ANGPTL1 expression suppress cancer cell motility and metastasis in lung cancer models?
Population
102 patients with lung cancer; lung and breast cancer cell lines; mice injected with cancer cell lines
Design
Preclinical
Authors
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May inform lung cancer prognosis; leaves open therapeutic targeting of ANGPTL1/SLUG pathway pending human trials.
Does ANGPTL1 expression suppress cancer cell motility and metastasis in lung cancer models?
ANGPTL1 represses lung cancer cell motility and metastasis by abrogating the expression of the EMT mediator SLUG via an integrin α(1)β(1)/FAK/ERK/SP1/miR-630 pathway.
Kuo et al. (2013) studied Lung cancer (n=102). ANGPTL1 expression vs. Low ANGPTL1 expression was evaluated on Clinical outcomes (invasion, lymph node metastasis, overall survival). High ANGPTL1 expression inversely correlates with invasion, lymph node metastasis, and poor clinical outcomes in patients with lung cancer.
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