Key result
Elevated oxidative stress in reoxygenated guinea pig ventricular myocytes is required for rapid NCX reactivation and subsequent Ca2+ overload.
Population
Guinea pig ventricular myocytes
Comparison
Hypoxia followed by reoxygenation, with or… vs Control conditions
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for oxidative stress-NCX interactions in reperfusion injury.
Elevated oxidative stress is an essential trigger for rapid NCX reactivation and subsequent Ca2+ overload during reoxygenation in cardiac myocytes.
Eigel et al. (2004) studied Hypoxia/reoxygenation injury. Oxidative stress / ROS was evaluated on NCX reactivation and Ca2+ overload. Elevated oxidative stress in reoxygenated guinea pig ventricular myocytes is required for rapid NCX reactivation and subsequent Ca2+ overload.
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