Key result
Raising fatty acid concentrations from 0.4 to 1 mM in perfused rat hearts lowered cardiac output and efficiency by ~20% and reduced anaplerotic pyruvate carboxylation 2.4-fold, while citrate release remained unchanged.
Population
semirecirculating work-performing rat hearts
Comparison
Increasing fatty acid concentrations from 0.4 to… vs 0.4 mM oleate-albumin
Design
Preclinical
Authors
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High fatty acid effects in rat hearts should not alter clinical management; hypothesis-generating for anaplerotic modulation in cardiac metabolism.
High fatty acid concentrations in working rat hearts differentially modulate anaplerotic pyruvate carboxylation and citrate release, with citrate release remaining limited and unchanged despite higher tissue citrate levels.
Vincent et al. (2004) studied this question. Increasing fatty acid concentrations (long-chain oleate or medium-chain octanoate) vs. 0.4 mM oleate-albumin was evaluated on Substrate fluxes through pathways leading to citrate synthesis and release. Raising fatty acid concentrations from 0.4 to 1 mM in perfused rat hearts lowered cardiac output and efficiency by ~20% and reduced anaplerotic pyruvate carboxylation 2.4-fold, while citrate release remained unchanged.
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