Why the study?
Does altering heart rate affect chloroform-epinephrine induced cardiac arrhythmia in dogs?
Population
chloroform-anesthetized dogs receiving epinephrine
Design
Preclinical
Authors
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Vagal rate slowing terminates experimental arrhythmia indirectly; hypothesis-generating for frequency-dependent mechanisms and should not yet inform clinical VT management.
Does altering heart rate affect chloroform-epinephrine induced cardiac arrhythmia in dogs?
In a canine model, vagal influence on ventricular arrhythmia is indirect and mediated through the frequency of excitation entering the ventricle, suggesting ventricular tachycardia in these conditions is a self-sustaining arrhythmia dependent on a critical frequency.
Robert L. Vick (1966) studied this question.
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