Key result
The positive lusitropic effect of beta-adrenoceptor stimulation was preserved in diabetic cardiomyopathy in rats, and beta3-adrenoceptor over-expression does not seem to affect this process.
Population
Healthy and diabetic rats (induced by IV streptozotocin injection, evaluated at 4 and 12 weeks)
Comparison
Beta-adrenergic stimulation with or without… vs Healthy rats
Design
Preclinical
Follow-up
4 and 12 weeks
Authors
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Rat model data on lusitropy in diabetic cardiomyopathy are hypothesis-generating; human studies needed before clinical translation.
In a rat model of diabetic cardiomyopathy, the positive lusitropic effect of beta-adrenoceptor stimulation is preserved despite diastolic dysfunction and beta3-adrenoceptor up-regulation.
Amour et al. (2008) studied Diabetic cardiomyopathy. Beta-adrenoceptor stimulation (dobutamine/isoproterenol) vs. Healthy rats was evaluated on Positive lusitropic effect of beta-adrenoceptors stimulation. The positive lusitropic effect of beta-adrenoceptor stimulation was preserved in diabetic cardiomyopathy in rats, and beta3-adrenoceptor over-expression does not seem to affect this process.
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