What question did this study set out to answer?

To determine the impact of 14 weeks of carnosine supplementation on circulating inflammatory markers and adipokines in adults diagnosed with prediabetes or well-controlled type 2 diabetes.

November 15, 2024NutrientsOpen Access

Carnosine Supplementation Has No Effect on Inflammatory Markers in Adults with Prediabetes and Type 2 Diabetes: A Randomised Controlled Trial

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Authors

SSSaeede SaadatiAustralian Regenerative Medicine Institute MCMaximilian de CourtenGeneral / Preventive / Lipids CDCyril DeceneuxRMIT University

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Implication

Randomized double-blind trial finds no effect of carnosine supplementation on inflammatory markers in adults with prediabetes or diabetes, indicating limited anti-inflammatory benefit.

Key Points

To determine the impact of 14 weeks of carnosine supplementation on circulating inflammatory markers and adipokines in adults diagnosed with prediabetes or well-controlled type 2 diabetes.
Secondary analysis of a double-blind randomized controlled trial (NCT02917928) conducted in N=49 eligible adults with prediabetes or well-controlled type 2 diabetes (mean HbA1c: 6.6 ± 0.7%).
Participants were randomly assigned to receive either 2 g/day of oral carnosine or a matching placebo for a 14-week intervention period.
Serum levels of MCP-1, IL-6, IL-10, CRP, TNF-α, adiponectin, leptin, adipsin, serpin, and resistin were quantified at baseline and after 14 weeks.
Carnosine supplementation led to no statistically significant differences in serum concentrations across all measured inflammatory biomarkers or adipokines compared to placebo (p > 0.05 for all).
Adjustment for potential confounding variables, including age, sex, body fat percentage, and visceral adipose tissue, did not alter the absence of significant treatment effects.

Cite This Study

Saadati et al. (2024) studied this question.

synapsesocial.com/papers/6a82de5f1a33da52dd1c2e91 https://doi.org/10.3390/nu16223900

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Implication

Randomized double-blind trial finds no effect of carnosine supplementation on inflammatory markers in adults with prediabetes or diabetes, indicating limited anti-inflammatory benefit.

Carnosine Supplementation Has No Effect on Inflammatory Markers in Adults with Prediabetes and Type 2 Diabetes: A Randomised Controlled Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Carnosine Supplementation Has No Effect on Inflammatory Markers in Adults with Prediabetes and Type 2 Diabetes: A Randomised Controlled Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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