Atrial natriuretic peptide and catecholamines in peripheral blood as indicators of cardiac dysfunction in the general population

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Why the study?

Are peripheral venous concentrations of IrANP and catecholamines sensitive indicators of cardiac dysfunction in the general population?

Structured PICO

Are peripheral venous concentrations of IrANP and catecholamines sensitive indicators of cardiac dysfunction in the general population?

Population

87 men aged 67 years from Gothenburg, comprising 42 with presumed cardiac dyspnoea and 45 random controls.

Intervention

Measurement of peripheral venous concentrations of immunoreactive atrial natriuretic peptide (IrANP), noradrenaline, and adrenaline.

Comparator

Random controls without presumed cardiac dyspnoea.

Outcome

Cardiac dysfunction evaluated by echocardiography and other non-invasive methods.surrogate

Peripheral venous IrANP is more closely related to cardiac function than catecholamines but is not a sensitive marker for early cardiac dysfunction.

No takes yet. Share an insight, caveat, or question.

IrANP and noradrenaline lack sensitivity for early cardiac dysfunction; leaves open their biomarker role in severe dyspnoea only.

Caidahl et al. (1988) studied this question.

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