Population
Mixture containing standard poliovirus and D3 particles (mutants with deletions in the capsid locus)
Design
Preclinical
Follow-up
Up to 40 passages
Authors
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D3 elimination and DX emergence under guanidine pressure are hypothesis-generating; further studies needed to clarify deletion mutant fitness in poliovirus populations.
Serial passage of poliovirus in guanidine leads to the elimination of D3 deletion mutants and the emergence of a novel DX deletion mutant.
Daniel R. Tershak (1982) studied this question.
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