Identifies and characterizes defective interfering particles of poliovirus I, showing they have shorter RNA but identical proteins to standard virus.
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Defective poliovirus particles merit model-based study; leaves open their in vivo role or therapeutic potential.
A class of defective interfering (DI) poliovirus particles has been identified. The first was found as a contaminant of a viral stock; others have been isolated by serial passage at a high multiplicity of infection. The DI particles are less dense than standard virus and sediment more slowly. Their ribonucleic acid (RNA) sediments more slowly than standard RNA and has a higher electrophoretic mobility. Competition hybridization experiments with double-stranded viral RNA indicate that DI RNA is 80 to 90% of the length of standard RNA. The proteins of DI particles are indistinguishable from those of standard poliovirus.
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Cole et al. (1971) studied this question.
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