November 1, 1958The Journal of Immunology
Immunochemical Studies of Poliovirus
Population
Partially purified concentrated poliovirus from monkey kidney tissue cultures
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Distinguishes poliovirus particle subtypes by infectivity and antigenicity; leaves open relevance to human disease or vaccines.
Structured PICO
P
Population
Partially purified concentrated poliovirus from monkey kidney tissue cultures
I
Intervention
Fractionation in the ultracentrifuge and infectivity/serologic assay
O
Outcome
Identification and characterization of distinct viral particles based on infectivity, immunologic specificity, and sedimentation coefficientsurrogate
This basic virology study identifies four distinct poliovirus particles based on their infectivity, immunologic specificity, and sedimentation properties.
Cite This Study
Roizman et al. (1958) studied this question.